This study assesses the agribusiness-enabling environment for cross-border trade in the Lower Mekong region by focusing on specific indicators of four key agricultural inputs: seed, fertilizer, pesticide, and fish fry. The study examines the country-level and regional issues in Thailand, Vietnam, and Cambodia with respect to (1) administrative (in)efficiency, (2) transaction costs, and (3) strength of the legal and regulatory framework, all with the ultimate objective of better informing agriculture sector decision-makers about the prevailing constraints to trade, investment, and economic growth. Overall, the assessment team found considerable variation across inputs and countries with respect to the time needed, cost, and complexity of the trade-related activities measured in the study.